CBD-rich cannabis (Phytocannabinoid Rich ) is better than single-molecule CBD…Here’s why……
A groundbreaking study has documented the superior therapeutic properties of whole plant Phytocannabinoid Rich ( PCR) CBD oil extract as compared to single-molecule CBD.
Entitled “Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol,”
These studies showed that administration of pure, single-molecule CBD resulted in a bell-shaped dose-response curve, meaning that when the amount of CBD exceeded a certain point its therapeutic impact declined dramatically. “Healing was only observed when CBD was given within a very limited dose range, whereas no beneficial effect was achieved at either lower or higher doses,” the authors observed. This characteristic of single-molecule CBD—manifested as a bell-shaped dose-response—imposes serious obstacles that limit its usefulness in a clinical context.
The scientists obtained a CBD-rich strain called clone 202 it was a mix from two high CBD dominant strains called Cannatonic and AC/DC ( the same strains that all Purity CBD oils are made from)
But a different dose-response pattern was observed when the clone 202 extract was administered to mice. Rather than showing a bell-shaped curve, where a therapeutic effect could only be achieved at a certain concentration of pure CBD, the whole plant CBD-rich extract caused a direct, dose-dependent inhibition of pain, inflammation, and TNFa production. “In stark contrast to purified CBD,” the Israeli team reported, “the clone extract…provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses.”
Moreover, the Israeli researchers found that a small amount of CBD in the clone extract (PCR) was needed for significant pain relief compared to the much larger amount of pure CBD (isolate )required to achieve the same analgesic effect. And whereas pure, single-molecule CBD precipitated a dramatic drop in efficacy if more than a specific dosage was administered, an “overdose” of whole plant CBD-rich extract did not undermine its therapeutic potency. When greater than an optimal dose of the clone 202 oil was administered, its effectiveness levelled off, suggesting that a medicinal plateau had been reached.
The Israeli study found that Cannabis clone 202 extract “is superior over CBD for the treatment of inflammatory conditions.” The greater efficiency of the whole plant extract might be explained by additive or synergistic interactions between CBD and dozens of minor phytocannabinoids and hundreds of non-cannabinoid plant compounds. “It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD,”
The key finding that CBD in the presence of other Cannabis components improves the dose-response is supported by recent reports documenting the anti-proliferative effect of cannabidiol on tumour cells and the inhibitory effect of CBD on bladder contractility.
So basically PCR CBD oil from Purity is far better than any single molecule CBD oil so when you’re looking for the best CBD OIL make sure it’s Phytocannabinoid Rich. ( PCR) if it doesn’t say it on the label it’s not PCR CBD.
Information from project cbd.org